Partial-thickness tears can have a lasting impact on pain and shoulder function. The REGENETEN◊ Bioinductive Implant leads to tendon healing without the need for sutured repair;1-4 offering patients an accelerated recovery and return to activity from sutured repair techniques.4,5
The REGENETEN Bioinductive Implant is a bioengineered scaffold made from highly purified type I collagen fibers. Following fixation using its efficient & suture-free technique, the REGENETEN Implant is resorbed and replaced by a new layer of tendon-like tissue within 6 months3,4,6.7 increasing tendon thickness.1-4,6-8 and creating an environment conducive to healing.1,2,6,8A decade of data has demonstrated a powerful impact on partial-thickness repair outcomes.1,8,9
Clinical studies have demonstrated the value of the REGENETEN Bioinductive Implant as an isolated treatment:
Apply the REGENETEN Implant over the bursal surface of the rotator cuff to help induce the formation of new tendon-like tissue.1,2,6,7
Post-operative rehabilitation protocols are a crucial factor in helping patients get back to their lives. In a study evaluating isolated use of the REGENETEN Implant in stable full-thickness rotator cuff tears, it was shown to help patients return to work 10 weeks faster and spend less than half the average time in a sling when compared to sutured repair.*4
Post-operative rehabilitation protocols are a crucial factor in helping patients get back to their lives. In a study evaluating isolated use of the REGENETEN Implant in stable full-thickness rotator cuff tears, it was shown to help patients return to work 70 days faster and spend less than half the average time in a sling when compared to sutured repair. *5
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* n=122. Study conducted in biomechanically stable full-thickness rotator cuff tears (n=60) comparing isolated REGENETEN Implant use to a transosseous equivalent repair.
1. D. J. Bokor, D. H. Sonnabend, L. Deady, B. Cass, A. A. Young, C. L. Van Kampen, S. P. Arnoczky. Healing of partial-thickness rotator cuff tears following arthroscopic augmentation with a highly-porous collagen implant: a 5-year clinical and MRI follow-up. Muscles Ligaments Tendons J. 2019; 9(3):338-347. doi: 10.32098/mltj.03.2019.07
2. Schlegel TF, Abrams JS, Angelo RL, Getelman MH, Ho CP, Bushnell BD. Isolated bioinductive repair of partial-thickness rotator cuff tears using a resorbable bovine collagen implant: two-year radiologic and clinical outcomes from a prospective multicenter study. J Shoulder Elbow Surg. 2021;30(8):1938-1948. doi:10.1016/j.jse.2020.10.022
3. Camacho-Chacon JA, Cuenca-Espierrez J, Roda-Rojo V, et al. Bioinductive collagen implants facilitate tendon regeneration in rotator cuff tears. J Exp Orthop. 2022;9(1):53. Published 2022 Jun 8. doi:10.1186/s40634-022-00495-7
4. Camacho Chacón JA, Roda Rojo V, Martin Martinez A, et al. An isolated bioinductive repair vs sutured repair for full-thickness rotator cuff tears: 2-year results of a double blinded, randomized controlled trial. J Shoulder Elbow Surg. 2024;33(9):1894-1904. doi:10.1016/j.jse.2024.03.043
5. Bushnell BD, et al. Orthop J Sports Med. 2021;9(8):23259671211027850.
6. Van Kampen C, Arnoczky S, Parks P, et al. Tissue-engineered augmentation of a rotator cuff tendon using a reconstituted collagen scaffold: a histological evaluation in sheep. Muscles Ligaments Tendons J. 2013;3(3):229-235. Published 2013 Aug 11.
7. Arnoczky SP, Bishai SK, Schofield B, et al. Histologic Evaluation of Biopsy Specimens Obtained After Rotator Cuff Repair Augmented With a Highly Porous Collagen Implant. Arthroscopy. 2017;33(2):278-283. doi:10.1016/j.arthro.2016.06.047
8. Bokor DJ, Sonnabend D, Deady L, et al. Evidence of healing of partial-thickness rotator cuff tears following arthroscopic augmentation with a collagen implant: a 2-year MRI follow-up. Muscles Ligaments Tendons J. 2016;6(1):16-25. Published 2016 May 19. doi:10.11138/mltj/2016.6.1.016
9. Warren JR, Domingo-Johnson ER, Sorensen AA, Cheng AL, Latz KH, Cil A. Bioinductive patch as an augmentation for rotator cuff repair, a systematic review and meta-analysis. J Shoulder Elbow Surg. 2024;33(11):2515-2529. doi:10.1016/j.jse.2024.05.002
10. Ruiz Ibán MÁ, García Navlet M, Moros Marco S, et al. Augmentation of a Transosseous-Equivalent Repair in Posterosuperior Nonacute Rotator Cuff Tears With a Bioinductive Collagen Implant Decreases the Retear Rate at 1 Year: A Randomized Controlled Trial. Arthroscopy. 2024;40(6):1760-1773. doi:10.1016/j.arthro.2023.12.014
11. Smith+Nephew. REGENETEN Implant Partial-Thickness Rehabilitation Protocol.
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